The diagnosis of chronic lymphocytic leukemia requires a well-equipped lab that can analyse not only the shape and size of cells, but also the antigens (proteins) that these cells have on their surface. A careful lab analysis allows to distinguish CLL from other diseases with a different prognosis and treatment. Blood enlargement in a patient with chronic lymphocytic leukemia, where a lymphocyte increase is observed (cells dyed blue)

Image analysis by flow citometry. This lab method enables the differentiation and analysis of the different types of blood cells, both in healthy people and in leukemia patients

The tests performed on all CLL patients include a general and complete analysis, the study of the membrane antigens and the study of the bone marrow (where the disease originates). In addition, in specialized centres such as ours, various studies determine the rate of aggressiveness of the disease and the prognosis. These studies include the analysis of protein ZAP-70, CD38, study of chromosome abnormalities, thoracic and abdominal CT scan, etc. After the collection of previous data, the diagnosis is performed and the prognosis is established, as well as the treatment needed.